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Ex Vivo Assays (Langendorff Isolated Perfused Heart) are utilized because metabolites and off-target responses (autonomic, vascular) can mask the direct cardiac effects of a test article in vivo.

Informative and economical

High sensitivity and specificity
Explores electrophysiological and mechanical parameters
Quantifies coronary vascular resistance
Millisecond accuracy for measuring QT and QT instability
Identifies NOAEL
GLP compliant

The Langendorff Model