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QTest
Labs Studies are designed and conducted
to show the risk profile for potential
pharmacologic agents and therapeutic
devices. These studies are conducted
in both normal animals and on animals
with disease states that predisposed
to toxicities.
Our models provide assurance, with
high sensitivity and specificity that
the Pharmacologic agent or device
is safe for the cardiovascular system.
Qtest Labs investigates effects
on all important cardiovascular targets
including:
- Electrophysiological
- Ventricular Mechanical
- Vascular
- Baroreceptor sensitivity
- Cardiac Output and Fractionation
of Cardiac output.
When pharmacologic agents
Affect AV conduction we investigate
with the effect is supra-nodal and
or infra-nodal.
We also investigate if a compound
produces an arrhythmia de novo, or
if it maybe provoked by programmed
electrical stimulation. |
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We
utilize a series of models to expand the
range of cardiovascular data that can be
assessed on test articles. These models
also ensure that studies are more comprehensive
and affordable. For example, we can test
a compound in a Langendorff preparation
and expand the testing of a compound by
putting them into (in-vivo) models to determine
mechanisms of action. QTest Labs reads and
interprets ECGs from sponsor driven safety
pharmacology and toxicology studies. All
are conducted under GLP compliance and meet
standards set by the ICH guidelines.
Click on one of our models below to learn
more about the particulars:
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