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Disease Model
Tests potential drug toxicity
- Permissive to torsade
de pointes
- Realistic to target
populations
- Conscious, Anesthetized
or Langendorff preparations
- Shows potential of test
articles on LV, hypertrophy,
heart failure or diabetes
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Toxicity is often exaggerated
in states such as left ventricular
hypertrophy, heart failure or
diabetes. Therefore potential
drug toxicity is sought in these
models.
Stable heart failure develops
within 4 weeks following ligation
of coronary arteries. Effects
of test articles on degree (i.e.,
infarct size, severity and type
of arrhythmia) and on treatment
(i.e., inotropic and/or arrhythmic
response) of heart failure may
be studied. |
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