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Ex Vivo Assays (Langendorff Isolated Perfused Heart) are utilized because metabolites and off-target responses (autonomic, vascular) can mask the direct cardiac effects of a test article in vivo.
Informative and economical
- High sensitivity and specificity
- Explores electrophysiological and mechanical parameters
- Quantifies coronary vascular resistance
- Millisecond accuracy for measuring QT and QT instability
- Identifies NOAEL
- GLP compliant